Insulin resistance and beta-cell dysfunction in relation to cardiometabolic risk patterns.

Insulin resistance and beta-cell dysfunction in relation to cardiometabolic risk patterns.

J Clin Endocrinol Metab. 2018 Mar 23;:

Authors: Wang T, Zhao Z, Xu Y, Qi L, Xu M, Lu J, Li M, Chen Y, Dai M, Zhao W, Ning G, Wang W, Bi Y

Abstract
Context: Insulin resistance and beta-cell dysfunction are two major defects synergistically inducing the development of diabetes and related cardiometabolic disorders.
Objective: To investigate the independent and joint associations of insulin resistance and beta-cell dysfunction with the prevalences of multiple cardiometabolic disorders including obesity, central obesity, diabetes, dyslipidemia, and hypertension.
Design: and Settings A nationally representative population of 93,690 Chinese adults.
Main Outcome Measures: Insulin resistance and beta-cell dysfunction were assessed by homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA of beta-cell function (HOMA-B), respectively.
Results: High HOMA-IR was independently associated with high prevalences of all estimated cardiometabolic disorders; while low HOMA-B was independently associated with high prevalences of diabetes, dyslipidemia, and hypertension but low prevalence of obesity and central obesity. When examined jointly, the associations of HOMA-IR and HOMA-B with multiple cardiometabolic disorders showed different patterns with varying magnitudes: the strongest joint associations were observed for diabetes, with low HOMA-B associating with high prevalence of diabetes regardless of HOMA-IR; joint associations with prevalences of dyslipidemia and hypertension appeared to be additive and had moderate changing trends; and low HOMA-B was not associated with high prevalence of obesity or central obesity unless combined with high HOMA-IR.
Conclusions: Insulin resistance was associated with more prevalent cardiometabolic disorders than beta-cell dysfunction, and combinations of insulin resistance and beta-cell dysfunction showed distinct relations with cardiometabolic risk patterns in Chinese adults.

PMID: 29590437 [PubMed - as supplied by publisher]

https://ift.tt/2GCsBc5