Long non-coding RNA expression profiles reveals AK098783 is a biomarker to predict poor prognosis in patients with colorectal cancer.

Long non-coding RNA expression profiles reveals AK098783 is a biomarker to predict poor prognosis in patients with colorectal cancer.

Jpn J Clin Oncol. 2018 Mar 26;:

Authors: Wang X, Liu F, Liu X, Wang F, Liao X, Chen Y, Mao Y, Hua D, Ge X

Abstract
Background: Long non-coding RNAs (lncRNAs) have essential regulatory function, yet their roles in colorectal cancer (CRC) are not well understood.
Materials and methods: Microarray was applied to detect lncRNAs expression profiles in tumor tissues, liver metastasis and paired adjacent normal tissues of CRC. And using RT-PCR to verify chip results.
Results: A total of 10 680 lncRNAs demonstrated differential expressions (fold change ≥2) between tumor tissues and adjacent normal tissues; furthermore there were 2970 lncRNAs, which showed different expression level between CRC tissues with liver metastasis and adjacent normal tissues. Especially, lncRNA-AK098783 expression level was frequently higher in cancerous tissues than corresponding noncancerous tissue. Higher AK098783 expression was significantly correlated with shortened overall survival (P < 0.001) and distant metastasis (P < 0.001).
Conclusions: Our results suggest that AK098783 is involved in distant metastasis and dramatically associated with poor prognosis in patients with CRC.

PMID: 29590393 [PubMed - as supplied by publisher]

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