Publication date: May 2018
Source:Neoplasia, Volume 20, Issue 5
Author(s): Chun-Hua Wang, Shi-Xun Lu, Li-Li Liu, Yong Li, Xia Yang, Yang-Fan He, Shi-Lu Chen, Shao-Hang Cai, Hong Wang, Jing-Ping Yun
The ubiquitin-proteasome system is implicated in cell apoptosis that is frequently dysregulated in human cancers. POH1/rpn11/PSMD14, as a part of the 19S proteasomal subunit, contributes to the progression of malignancy, but its role in apoptosis remains unclear. Here, we showed that POH1 expression was increased and associated with poor outcomes in three independent cohorts of patients with hepatocellular carcinoma (HCC), esophageal cancer (EC), and colorectal cancer (CRC). The knockdown of POH1 significantly inhibited tumor cell proliferation and induced apoptosis mediated by the mitochondrial pathway in vitro. Intratumoral injection of POH1 small interfering RNA (siRNA) significantly reduced the progression of tumor growth and induced apoptosis in vivo. Furthermore, p53 or Bim siRNA markedly attenuated the apoptosis induced by POH1 depletion. POH1 depletion resulted in cell apoptosis by increasing the stability of p53 and Bim and inhibiting their ubiquitination. Overall, POH1 knockdown induced cell apoptosis through increased expression of p53 and Bim via enhanced protein stability and attenuated degradation. Thus, POH1 may serve as a potential prognostic marker and therapeutic target in human cancers.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Πέμπτη 22 Μαρτίου 2018
POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim
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- Diagnostic accuracy of multiplex real-time PCR app...
- Editorial Advisory Board
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- Masthead
- Full-Field-of-View Time-Harmonic Elastography of t...
- Focused Ultrasound-Induced Suppression of Auditory...
- Ultrasound Irradiation Combined with Hepatocyte Gr...
- Ultrasound-Guided Percutaneous Core Needle Biopsy ...
- Case of a fractured human bone fragment as an endo...
- Klippel-Trenaunay-Weber syndrome as a cause of chr...
- Testicular torsion in a patient with Ehlers-Danlos...
- Two cases of hypokalaemic rhabdomyolysis: same but...
- A rare presentation of haematuria: hip prosthesis ...
- Importance of source images of time-of-flight magn...
- Rhinofacialentomophthoromycosis
- Central congenital hypothyroidism caused by matern...
- Tarsal buckle with conjunctival prolapse following...
- Complication of intraprosthetic dislocation of dua...
- Myocarditis secondary to smallpox vaccination
- Parkinsons disease with hypocalcaemia: adult prese...
- Diffusion-weighted imaging is helpful in the accur...
- Risk prediction for Staphylococcus aureus surgical...
- [Effect of ozone on Staphylococcus aureus coloniza...
- Surgical site infection related to use of elastome...
- Prognostic and Predictive Factors for Renal Cell C...
- Development of decellularized amniotic membrane as...
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- Ecological factors associated with pre-dispersal p...
- Combining baseline TMTV and gene profiling for a b...
- Reply: Interim FDG-PET/CT in primary mediastinal d...
- H. William Strauss, Giuliano Mariani, Duccio Volte...
- Glioblastoma multiforme: another potential applica...
- Bone radionuclide therapy and increased survival w...
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- The diagnostic value of 18 F–FDG-PET/CT and MRI in...
- Preoperative prediction of microvascular invasion ...
- Comparison of positron emission tomography/compute...
- Interpretation criteria for FDG PET/CT in multiple...
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- Reply to: “All that glitters is not gold – new rec...
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- Favorable versus unfavorable prognostic groups by ...
- EANM guideline for radionuclide therapy with radiu...
- Life is not black and white, nor just Shades of Gray
- EANM guidelines for radionuclide therapy of bone m...
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- Complex Interplay between Epitope Specificity and ...
- Cerium dioxide (CeO2) nanoparticles decrease arsen...
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- A comparison of the use of commercial and diluent ...
- Seagrass Halophila stipulacea: Capacity of accumul...
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- Autoantibodies targeting TLR and SMAD pathways def...
- Cancer Pain Syndromes
- Mechanisms of, and Adjuvants for, Bone Pain
- Methadone
- Intracell Heat Shock Protein 70 Expression and Nas...
- Post Parotidectomy Quality of Life in Patients wit...
- The Journal of Dermatology, Ahead of Print.
- The Journal of Dermatology, Ahead of Print.
- Intracell Heat Shock Protein 70 Expression and Nas...
- Post Parotidectomy Quality of Life in Patients wit...
- Cytological diagnosis of mazabraud's syndrome
- Utility of cytokeratin7 immunocytochemistry in the...
- Endoscopic ultrasound-guided cytodiagnosis of adre...
- Utility of cytospin and cell block technology in e...
- Cystic schwannoma of tongue masquerading as mucoce...
- Role of endoscopic ultrasound-guided fine-needle a...
- Pilot study of an open-source image analysis softw...
- Gata3 immunohistochemical staining is a useful mar...
- Primary splenic angiosarcoma with liver metastasis...
- Comparison of conventional smear and liquid-based ...
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- Comparing the efficacy of leishman–giemsa cocktail...
- Cytological findings of a rare case of transitiona...
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- Insights into the Psychology of Trauma Should Info...
- The Emerging Impact of Social Media on Cancer Pati...
- Families’ Sense of Abandonment When Patients Are R...
- Serial Troponin for Early Detection of Nivolumab C...
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- Regulation of human dendritic cell immune function...
- Biologicals in der Rhinologie – Individualisierte ...
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- Immuntherapie – Die neue Ära in der Onkologie
- The relationship between urban form and air pollut...
- Incidences of mortality of Indian peafowl Pavo cri...
- Mechanical Allodynia Predicts Better Outcome of Su...
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