The circadian rhythm-related MTNR1B genotype, gestational weight gain, and postpartum glycemic changes.

The circadian rhythm-related MTNR1B genotype, gestational weight gain, and postpartum glycemic changes.

J Clin Endocrinol Metab. 2018 Mar 23;:

Authors: Nisa H, Qi KHT, Leng J, Zhou T, Liu H, Li W, Wang L, Li N, Hu G, Qi L

Abstract
Context: Disturbed circadian rhythms and sleep quality during pregnancy have been related to gestational weight gain and gestational diabetes mellitus (GDM), which affect postpartum glucose metabolism and future risk of type 2 diabetes.
Objective: We assessed whether the circadian rhythm-related melatonin receptor 1B (MTNR1B) genotype was associated with 1-5 years of postpartum glycemic changes among women with a history of GDM; and whether gestational weight gain modified such associations.
Design, Settings, and Participants: The established circadian rhythm-associated MTNR1B genetic variant (rs10830963) was genotyped in 1025 Chinese women with a history of GDM. Body weight and glycemic traits during and after pregnancy were longitudinally collected.
Main Outcome Measure: The main outcome measure was postpartum glycemic changes.
Results: We found women carrying different MTNR1B genotypes showed distinct postpartum changes in 2-h OGTT glucose: 0.36, 0.20, and -0.19 mmol/L per additional copy of the shorter sleep duration related G allele in women with inadequate, adequate, and excessive gestational weight gain, respectively (p for interaction=0.028). The corresponding changes in fasting glucose were 0.14, 0.13, and 0.01 mmol/L, though the modification effect of gestational weight gain on the genetic association was marginally significant (p for interaction= 0.067).
Conclusions: Our findings suggest that gestational weight gain may modify the circadian rhythm-related MTNR1B genetic variant on long term glycemic changes, highlighting the significance of gestational weight management in diabetes prevention among women with GDM.

PMID: 29590381 [PubMed - as supplied by publisher]

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