The Utility of the Total Neuropathy Score as an Instrument to Assess Neuropathy Severity in Chronic Kidney Disease: A Validation Study

Publication date: Available online 6 March 2018
Source:Clinical Neurophysiology
Author(s): Tushar Issar, Ria Arnold, Natalie C.G. Kwai, Bruce A. Pussell, Zoltan H. Endre, Ann M. Poynten, Matthew C. Kiernan, Arun V. Krishnan
ObjectiveTo demonstrate construct validity of the Total Neuropathy Score (TNS) in assessing peripheral neuropathy in subjects with chronic kidney disease (CKD).Methods113 subjects with CKD and 40 matched controls were assessed for peripheral neuropathy using the TNS. An exploratory factor analysis was conducted and internal consistency of the scale was evaluated using Cronbach's alpha. Construct validity of the TNS was tested by comparing scores between case and control groups.ResultsFactor analysis revealed valid item correlations and internal consistency of the TNS was good with a Cronbach's alpha of 0.897. Subjects with CKD scored significantly higher on the TNS (CKD: median, 6, interquartile range, 1-13; controls: median, 0, interquartile range, 0-1; p<0.001). Subgroup analysis revealed construct validity was maintained for subjects with stages 3-5 CKD with and without diabetes.ConclusionsThe TNS is a valid measure of peripheral neuropathy in patients with CKD.SignificanceThe TNS is the first neuropathy scale to be formally validated in patients with CKD.



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