Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers.

Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers.

Adv Ther. 2018 Mar 06;:

Authors: Haigentz M, Suarez C, Strojan P, Rodrigo JP, Rinaldo A, Bradford CR, Corry J, Takes RP, Ferlito A

Abstract
The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.

PMID: 29511982 [PubMed - as supplied by publisher]

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