Adipsic diabetes insipidus revealing a bifocal intracranial germinoma.

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Adipsic diabetes insipidus revealing a bifocal intracranial germinoma.

Ann Endocrinol (Paris). 2017 Jul;78(3):141-145

Authors: Kreutz J, Potorac I, Lutteri L, Gennigens C, Martin D, Daly AF, Bonneville JF, Tshibanda L, Beckers A

Abstract
Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the case of a patient with bifocal intracranial germinoma, diagnosed due to symptoms mainly caused by adipsic diabetes insipidus. This is, to our knowledge, the first case of adipsic diabetes insipidus revealing an intracranial germinoma reported in the literature. We describe the diagnostic procedures and the three-year follow-up of this patient. Management of intracranial germ-cell tumors is made complex by the wide range of histological features. Although germinomas have a generally better prognosis than most nongerminomatous tumors, they can have severe or even life-threatening presentations. Adipsic diabetes insipidus is one such severe presentation and its rarity can make it difficult to recognize and manage. Awareness of this potential entity is therefore important for clinical practice.

PMID: 28483362 [PubMed - indexed for MEDLINE]

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