Numerical Imbalances of Chromosome 7 in Oral Squamous Cell Carcinoma.

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Numerical Imbalances of Chromosome 7 in Oral Squamous Cell Carcinoma.

Anticancer Res. 2018 04;38(4):2339-2342

Authors: Mastronikolis NS, Tsiambas E, Fotiades PP, Baliou E, Karameris A, Peschos D, Mastronikolis SN, Asimakopoulos AD, Giannakopoulos X, Ragos V

Abstract
BACKGROUND: Oral squamous cell carcinoma (OSCC) is an aggressive neoplasm. Many chromosomal and gene alterations have been identified in OSCC, including structural and numerical changes. In this study, we implemented a molecular assay of chromosome 7 (Chr7) in order to investigate the level of its numerical instability in OSCC.
MATERIALS AND METHODS: Using tissue microarray technology, 30 primary OSCCs were cored and re-embedded into one recipient block. Chromogenic in situ hybridization assay was performed based on Chr7 centromeric probedetection.
RESULTS: Chr 7 numerical analysis detected polysomy (trisomy/ tetrasomy) in 4/30 (13.3%) of the examined tissue OSCC cores. Statistical significance was assessed correlating Chr7 numerical aberrations with stage (p=0.015), especially detected in cases not related to human papillomavirus (HPV) (p=0.01).
CONCLUSION: Although Chr7 polysomy is a relatively rare gross genetic event in OSSC, it affects their biological behavior leading toa progressively aggressive phenotype (advanced stage). Furthermore, Chr7 polysomy is observed more frequently in non-viral (HPV) cases.

PMID: 29599358 [PubMed - indexed for MEDLINE]

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