Oropharyngeal squamous cell carcinoma induces an innate systemic inflammation, affected by the size of the tumor and the lymph node spread.

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Oropharyngeal squamous cell carcinoma induces an innate systemic inflammation, affected by the size of the tumor and the lymph node spread.

Clin Otolaryngol. 2018 Apr 21;:

Authors: Kågedal Å, Millrud CR, Häyry V, Kumlien Georén S, Lidegran M, Munck-Wikland E, Cardell LO

Abstract
OBJECTIVES: Inflammation is known to be associated with the progression of cancer. The study was designed to characterize the systemic inflammation in patients with oropharyngeal squamous cell carcinoma (OPSCC) and investigate its relation to tumor size, ability to metastasize and HPV status.
MATERIALS AND METHODS: Blood was obtained from 58 patients with OPSCC and 90 healthy controls and analyzed with leukocyte differential count.
RESULTS: The OPSCC patients displayed an increased number of neutrophils and monocytes, whereas the lymphocytes were suppressed compared to the healthy controls. The neutrophils to lymphocyte ratio (NLR) and the monocyte to lymphocyte ratio (MLR) were calculated and patients with large tumors exhibited high NLR and MLR. Further, patients with regional lymph node spread displayed a low NLR and MLR. Patients with HPV positive tumors (n = 48), had a lower NLR than the patients (n=8) with HPV negative tumors.
CONCLUSION: This study demonstrates that patients with OPSCC have an increased systemic inflammation that is affected by the HPV status, the size of the tumor and lymph node spread. This article is protected by copyright. All rights reserved.

PMID: 29679522 [PubMed - as supplied by publisher]

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