PROGRAD – An observational study of the prognosis of inpatients evaluated for palliative radiotherapy

Publication date: Available online 3 April 2018
Source:Radiotherapy and Oncology
Author(s): Andre Tsin Chih Chen, Geovanne Pedro Mauro, Flavia Gabrielli, Cristiane de Lacerda Gonçalves Chaves, Igor Castro, Karina Moutinho Vasconcelos, Milena Reis, Thalita Saraiva, Heloisa Andrade de Carvalho
Background and purposeLow-and-middle-income countries have resource constraints and waiting lists for radiotherapy (RT). In this context, we sought to determine the survival of inpatients evaluated for palliative RT in a large referral cancer center in Brazil.Material and methodsFrom November 2014 through December 2015, we enrolled 333 inpatients with palliative RT evaluation requests in this prospective observational study. We applied Palliative Prognostic Index (PPI) and Survival Prediction Score using Number of Risk Factors (NRF). Primary endpoint was overall survival. Secondary endpoints were survival by PPI and NRF. (ClinicalTrials.gov number, NCT02312791).ResultsMedian survival (MS) for the entire cohort was 73 days. PPI ≤2 had MS of 120 days; PPI 2.5–4 had MS of 55 days (HR 1.84; 95% CI, 1.07–3.16); PPI >4 had MS of 39 days (HR 3.45; 95% CI, 2.07–5.74) (p < .0001). NRF 0–1 had MS of 129 days; NRF 2 had MS of 73 days (HR 1.74; 95% CI 0.89–3.38); NRF 3 had MS of 40 days (HR 2.95; 95% CI, 1.50–5.78) (p < .0001).ConclusionInpatients with palliative RT requests seem to have an overall poor survival. PPI and NRF can define subgroups with different prognosis. This could help hospitals and healthcare systems to standardize criteria for prioritization and contribute for fairness.



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