Short-term repeatability of insulin resistance indexes in older adults. The Atherosclerosis Risk in Communities Study.

Short-term repeatability of insulin resistance indexes in older adults. The Atherosclerosis Risk in Communities Study.

J Clin Endocrinol Metab. 2018 Mar 29;:

Authors: Poon AK, Meyer ML, Reaven G, Knowles JW, Selvin E, Pankow JS, Couper D, Loehr L, Heiss G

Abstract
Context: The homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) are insulin resistance indexes routinely used in clinical and population-based studies, but their short-term repeatability are not well characterized.
Objective: To quantify the short-term repeatability of insulin resistances indexes and their analytes, consisting of fasting glucose and insulin for HOMA-IR, and triglyceride and high-density lipoprotein cholesterol (HDL-C) for TG/HDL-C.
Design: Prospective cohort study.
Participants: A total of 102 adults 68 to 88 years old without diabetes attended an initial exam and repeat exam (mean 46 days; range 28 to 102 days). Blood samples were collected, processed, shipped, and assayed following a standardized protocol.
Main outcome measures: Repeatability was quantified using the intraclass correlation coefficient (ICC) and within-person coefficient of variation (CV). Minimum detectable change (MDC95) and minimum detectable difference (MDD95) were quantified.
Results: For HOMA-IR, insulin, and fasting glucose, the ICCs were 0.70, 0.68, and 0.70; their respective within-person CVs were 30.4%, 28.8%, and 5.6%. For TG/HDL-C, triglyceride, and HDL-C, the ICCs were 0.80, 0.68, and 0.91; their respective within-person CVs were 23.0%, 20.6%, and 8.2%. The MDC95 for HOMA-IR was 2.3 and for TG/HDL-C was 1.4. The MDD95 for a sample of n=100 for HOMA-IR was 0.8 and for TG/HDL-C was 0.6.
Conclusions: Short-term repeatability was fair to good for HOMA-IR and excellent for TG/HDL-C according to suggested benchmarks, reflecting the short-term variability of their analytes. These measurement properties can inform the use of these indexes in clinical and population-based studies.

PMID: 29618016 [PubMed - as supplied by publisher]

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