Publication date: Available online 27 April 2018
Source:Trends in Biochemical Sciences
Author(s): Caitlyn Q Herr, Robert P. Hausinger
Since their discovery in the 1960s, the family of Fe(II)/2-oxoglutarate-dependent oxygenases has undergone a tremendous expansion to include enzymes catalyzing a vast diversity of biologically important reactions. Recent examples highlight roles in controlling chromatin modification, transcription, mRNA demethylation, and mRNA splicing. Others generate modifications in tRNA, translation factors, ribosomes, and other proteins. Thus, oxygenases affect all components of molecular biology's central dogma, in which information flows from DNA to RNA to proteins. These enzymes also function in biosynthesis and catabolism of cellular metabolites, including antibiotics and signaling molecules. Due to their critical importance, ongoing efforts have targeted family members for the development of specific therapeutics. This review provides a general overview of recently characterized oxygenase reactions and their key biological roles.
https://ift.tt/2s21X41
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Μαΐου
(7473)
-
▼
Μαΐ 23
(315)
- Case 16-2018: A 45-Year-Old Man with Fever, Thromb...
- Evolution of pituitary surgery in a tertiary centre
- Novel autosomal recessive LAMA3 and PLEC variants ...
- Varicella zoster virus as a possible trigger for t...
- Novel autosomal recessive LAMA3 and PLEC variants ...
- Varicella zoster virus as a possible trigger for t...
- Manipulating macrophage polarization and function ...
- Effects of treatment with an angiotensin 2 recepto...
- A pedunculated aldosterone‐producing adenoma drain...
- Long‐term outcomes and molecular analysis of a lar...
- Young age is associated with increased rates of re...
- Chronic Urticaria: Comparisons of US, European, an...
- Trapping fresh sea breeze in desert? Health status...
- Split-thickness skin grafting using grafts of diff...
- FACE‐Q Skin Cancer Module for measuring patient‐re...
- FACE‐Q Skin Cancer Module for measuring patient‐re...
- Anthropogenic activities impact on atmospheric env...
- Chronic Urticaria: Comparisons of US, European, an...
- Bullous pemphigoid complicated by necrotising fasc...
- Eyelid sebaceous carcinoma in situ presenting as h...
- Bullous pemphigoid complicated by necrotising fasc...
- Eyelid sebaceous carcinoma in situ presenting as h...
- Environmentally enriched pigs have transcriptional...
- The mediating role of phosphodiesterase type 4 in ...
- Factors underlying risk taking in heroin-dependent...
- Two single-nucleotide polymorphisms of the RELN ge...
- The effect of natural antioxidants in cyclophospha...
- Prediction of skin anti‐aging clinical benefits of...
- Prediction of skin anti‐aging clinical benefits of...
- Synthesis, molecular modelling studies and biologi...
- Pyrroloquinoline scaffold-based 5-HT6R ligands: sy...
- Molecular dynamics simulations of viral neuraminid...
- Expedient synthesis and biological evaluation of a...
- Synthesis and biophysical properties of 5’-thio-2’...
- Facilely Accessible Quinoline Derivatives as Poten...
- A prospective observational study of pigmented nae...
- Phase II Study of Everolimus and Octreotide LAR in...
- A prospective observational study of pigmented nae...
- Manipulating macrophage polarization and function ...
- Sublingual immunotherapy for pediatric allergic co...
- Evaluation of idiopathic olfactory loss with chemo...
- Comparison of outcomes following culture‐directed ...
- Evolving patterns in the diagnosis and management ...
- Effects of meta-tetrahydroxyphenylchlorin photodyn...
- Serum zonulin is associated with presence and seve...
- Acute generalized exanthematous pustulosis due to ...
- The genome sequence of a SNP type 3K strain of Myc...
- Acute generalized exanthematous pustulosis due to ...
- How to avoid the inappropriate use of antibiotics ...
- Breaking paradigms in severe epistaxis: the import...
- Obstructive sleep apnea is associated with increas...
- Peritonsillar and deep neck infections: a review o...
- Nasal mucociliary transportability of male and fem...
- Comparison between clinical and audiological resul...
- Genomic profile of a squamous cell carcinoma ex pl...
- Ototoxicity of boric acid powder in a rat animal m...
- Translation and adaptation of the Radiotherapy Ede...
- Hearing in Noise Test, HINT‐Brazil, in normal‐hear...
- Effect of antioxidant supplementation on the audit...
- Effect of caffeine on vestibular evoked myogenic p...
- Undifferentiated high‐grade pleomorphic sarcoma of...
- Unusual coexisting thyroglossal duct cyst and seco...
- Rosacea‐like cutaneous localization of small lymph...
- The significance of spectrophotometric image analy...
- Split‐axilla comparison study of 0.5‐MHz, invasive...
- Detection of hydroquinone by Raman spectroscopy in...
- Anesthesia effects on the low frequency blood flow...
- Sequels to tattoo removal by caustic products
- Use of silicone gel to enhance skin wound healing ...
- Thyroid function in hidradenitis suppurativa: a po...
- Erythrodermic pityriasis rubra pilaris managed at ...
- Cutaneous sarcoidosis: a new subset in the spectru...
- Immunohistochemical and molecular analysis of spit...
- Perforating folliculitis in association with liver...
- Pemphigus foliaceus and acquired haemophilia: a ra...
- Development of angio‐oedema after omalizumab injec...
- Intravenous immunoglobulins in dermatology. Part 1...
- Intravenous immunoglobulins in dermatology. Part 2...
- A comparison of intraoperative haemostatic techniq...
- Comorbid inner ear disorders in 50 patients with c...
- Thyroid function in hidradenitis suppurativa: a po...
- Erythrodermic pityriasis rubra pilaris managed at ...
- Chilblains accompanying interleukin‐1 receptor‐ass...
- Pemphigus foliaceus and acquired haemophilia: a ra...
- Development of angio‐oedema after omalizumab injec...
- Disseminated interstitial granuloma annulare assoc...
- Intravenous immunoglobulins in dermatology. Part 1...
- Intravenous immunoglobulins in dermatology. Part 2...
- Comparison of PCR‐based methods for the diagnosis ...
- When passion hurts: adverse cutaneous reaction to ...
- Cutaneous melanoma in France in 2015 attributable ...
- Systematic review of platelet‐rich plasma (PRP) pr...
- Split face comparison between common concentration...
- JCD Commentary—June 2018
- Issue Information
- Prevalence and risk factors for injection site ski...
- Characterization of asthma in the adolescent popul...
- Longitudinal evaluation of clustering of chronic s...
- Atopic asthma after rhinovirus‐induced wheezing is...
- Renal complications of lipodystrophy: A closer loo...
-
▼
Μαΐ 23
(315)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τετάρτη 23 Μαΐου 2018
Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Μαΐου
(7473)
-
▼
Μαΐ 23
(315)
- Case 16-2018: A 45-Year-Old Man with Fever, Thromb...
- Evolution of pituitary surgery in a tertiary centre
- Novel autosomal recessive LAMA3 and PLEC variants ...
- Varicella zoster virus as a possible trigger for t...
- Novel autosomal recessive LAMA3 and PLEC variants ...
- Varicella zoster virus as a possible trigger for t...
- Manipulating macrophage polarization and function ...
- Effects of treatment with an angiotensin 2 recepto...
- A pedunculated aldosterone‐producing adenoma drain...
- Long‐term outcomes and molecular analysis of a lar...
- Young age is associated with increased rates of re...
- Chronic Urticaria: Comparisons of US, European, an...
- Trapping fresh sea breeze in desert? Health status...
- Split-thickness skin grafting using grafts of diff...
- FACE‐Q Skin Cancer Module for measuring patient‐re...
- FACE‐Q Skin Cancer Module for measuring patient‐re...
- Anthropogenic activities impact on atmospheric env...
- Chronic Urticaria: Comparisons of US, European, an...
- Bullous pemphigoid complicated by necrotising fasc...
- Eyelid sebaceous carcinoma in situ presenting as h...
- Bullous pemphigoid complicated by necrotising fasc...
- Eyelid sebaceous carcinoma in situ presenting as h...
- Environmentally enriched pigs have transcriptional...
- The mediating role of phosphodiesterase type 4 in ...
- Factors underlying risk taking in heroin-dependent...
- Two single-nucleotide polymorphisms of the RELN ge...
- The effect of natural antioxidants in cyclophospha...
- Prediction of skin anti‐aging clinical benefits of...
- Prediction of skin anti‐aging clinical benefits of...
- Synthesis, molecular modelling studies and biologi...
- Pyrroloquinoline scaffold-based 5-HT6R ligands: sy...
- Molecular dynamics simulations of viral neuraminid...
- Expedient synthesis and biological evaluation of a...
- Synthesis and biophysical properties of 5’-thio-2’...
- Facilely Accessible Quinoline Derivatives as Poten...
- A prospective observational study of pigmented nae...
- Phase II Study of Everolimus and Octreotide LAR in...
- A prospective observational study of pigmented nae...
- Manipulating macrophage polarization and function ...
- Sublingual immunotherapy for pediatric allergic co...
- Evaluation of idiopathic olfactory loss with chemo...
- Comparison of outcomes following culture‐directed ...
- Evolving patterns in the diagnosis and management ...
- Effects of meta-tetrahydroxyphenylchlorin photodyn...
- Serum zonulin is associated with presence and seve...
- Acute generalized exanthematous pustulosis due to ...
- The genome sequence of a SNP type 3K strain of Myc...
- Acute generalized exanthematous pustulosis due to ...
- How to avoid the inappropriate use of antibiotics ...
- Breaking paradigms in severe epistaxis: the import...
- Obstructive sleep apnea is associated with increas...
- Peritonsillar and deep neck infections: a review o...
- Nasal mucociliary transportability of male and fem...
- Comparison between clinical and audiological resul...
- Genomic profile of a squamous cell carcinoma ex pl...
- Ototoxicity of boric acid powder in a rat animal m...
- Translation and adaptation of the Radiotherapy Ede...
- Hearing in Noise Test, HINT‐Brazil, in normal‐hear...
- Effect of antioxidant supplementation on the audit...
- Effect of caffeine on vestibular evoked myogenic p...
- Undifferentiated high‐grade pleomorphic sarcoma of...
- Unusual coexisting thyroglossal duct cyst and seco...
- Rosacea‐like cutaneous localization of small lymph...
- The significance of spectrophotometric image analy...
- Split‐axilla comparison study of 0.5‐MHz, invasive...
- Detection of hydroquinone by Raman spectroscopy in...
- Anesthesia effects on the low frequency blood flow...
- Sequels to tattoo removal by caustic products
- Use of silicone gel to enhance skin wound healing ...
- Thyroid function in hidradenitis suppurativa: a po...
- Erythrodermic pityriasis rubra pilaris managed at ...
- Cutaneous sarcoidosis: a new subset in the spectru...
- Immunohistochemical and molecular analysis of spit...
- Perforating folliculitis in association with liver...
- Pemphigus foliaceus and acquired haemophilia: a ra...
- Development of angio‐oedema after omalizumab injec...
- Intravenous immunoglobulins in dermatology. Part 1...
- Intravenous immunoglobulins in dermatology. Part 2...
- A comparison of intraoperative haemostatic techniq...
- Comorbid inner ear disorders in 50 patients with c...
- Thyroid function in hidradenitis suppurativa: a po...
- Erythrodermic pityriasis rubra pilaris managed at ...
- Chilblains accompanying interleukin‐1 receptor‐ass...
- Pemphigus foliaceus and acquired haemophilia: a ra...
- Development of angio‐oedema after omalizumab injec...
- Disseminated interstitial granuloma annulare assoc...
- Intravenous immunoglobulins in dermatology. Part 1...
- Intravenous immunoglobulins in dermatology. Part 2...
- Comparison of PCR‐based methods for the diagnosis ...
- When passion hurts: adverse cutaneous reaction to ...
- Cutaneous melanoma in France in 2015 attributable ...
- Systematic review of platelet‐rich plasma (PRP) pr...
- Split face comparison between common concentration...
- JCD Commentary—June 2018
- Issue Information
- Prevalence and risk factors for injection site ski...
- Characterization of asthma in the adolescent popul...
- Longitudinal evaluation of clustering of chronic s...
- Atopic asthma after rhinovirus‐induced wheezing is...
- Renal complications of lipodystrophy: A closer loo...
-
▼
Μαΐ 23
(315)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου