Glucose-dependent insulinotropic polypeptide increases blood flow in adipose tissue of humans by recruiting capillaries.

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Glucose-dependent insulinotropic polypeptide increases blood flow in adipose tissue of humans by recruiting capillaries.

J Clin Endocrinol Metab. 2018 May 09;:

Authors: Asmar M, Asmar A, Simonsen L, Holst JJ, Bülow J

Abstract
Context and objektive: Glucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increase blood flow and triglyceride clearance in subcutaneous abdominal adipose tissue in lean humans. The present experiments were performed to determine whether the increase may involve capillary recruitment.
Design: Eight lean healthy volunteers were studied before and after 1-h infusion of GIP or saline during a hyperglycemic-hyperinsulinemic clamp, raising plasma glucose and insulin to postprandial levels. Abdominal subcutaneous adipose tissue blood flow (ATBF) was measured by the 133Xenon clearance technique, and microvascular volume was determined by contrast-enhanced ultrasound imaging.
Results: During infusion of saline and during the clamp, both ATBF (2.7 ± 0.5 ml min-1 100 g tissue-1) and microvascular volume remained unchanged throughout the experiments (P=NS). During GIP infusion plus clamp, ATBF increased ∼four fold to 11.4 ± 1.9 ml min-1 100 g tissue-1, P<0.001. Likewise, the contrast-enhanced ultrasound signal intensity, a measure of the microvascular volume, increased significantly one hour after infusion of GIP and the clamp (P=0.003), but not in control experiments.
Conclusion: The increase in ATBF during GIP infusion involves recruitment of capillaries in healthy lean subjects, which presumably increases the interaction of circulating lipoproteins with lipoprotein lipase thus probably promoting adipose tissue lipid uptake.

PMID: 29750414 [PubMed - as supplied by publisher]

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