Modern Approaches for the Discovery of Anti-Infectious Drugs for the Treatment of Neglected Diseases.

Modern Approaches for the Discovery of Anti-Infectious Drugs for the Treatment of Neglected Diseases.

Curr Top Med Chem. 2018 May 09;:

Authors: Bellera CL, Sbaraglini ML, Talevi A

Abstract
Neglected diseases comprise a number of infectious diseases historically endemic to low- and middle-income countries, though recently they have spread to high-income countries due to human migrations. In the past, pharmaceutical companies have shown hesitant to invest in these health conditions, due to the limited return on investment. As a result, the role of the academic sector and non-for-profit organizations in the discovery of new drugs for neglected diseases has been particularly relevant. <p> Here, we review recent applications of modern drug discovery technologies in the field of neglected diseases, including high-throughput screening, in silico screening and computer-aided drug design. The suitability and perspectives of each approach is discussed depending on the context, along with the technology and translational gaps influencing them.

PMID: 29741140 [PubMed - as supplied by publisher]

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