Abstract: Programmed cell death ligand 1 (PD-L1) expression by tumor cells plays an important role in the inhibition of T cell–mediated immune response in cancer. PD-L1 expression by tumor cells has been linked to poor prognosis in a wide variety of cancers. However, PD-L1 expression in cutaneous squamous cell carcinoma (cSCC) has been scarcely studied, and its role as a prognosis biomarker remains controversial. The association of PD-L1 expression and the metastatic risk in a series of cSCC was assessed. PD-L1 and CD8 immunostainings of full excision sections of 99 primary tumors and 24 lymphatic metastases were semiquantitatively evaluated. Primary cSCCs were grouped according to the development of lymphatic metastatic spread [metastasizing squamous cell carcinoma (MSCC)] (n = 48) or the absence of progression [nonmetastasizing squamous cell carcinoma (NMSCC)] (n = 51). PD-L1–positive expression (cut off ≥1%) was found in 26% NMSCCs and in 50% MSCCs (P = 0.02). PD-L1 association with an increased metastatic risk was confirmed in the multivariate analysis (P
https://ift.tt/2KbXfY1
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- The Samarco mine tailing disaster: A possible time...
- Hazard potential of widespread but hidden historic...
- Mechanochemical synthesis of novel heterostructure...
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- Information for Readers
- Editorial Board
- The multidisciplinary tumor board for the manageme...
- Subject index
- CME examination
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- June iotaderma (#292)
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- Answers to CME examination
- Should medical students follow up on skin biopsy r...
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- Author index∗∗January, pp. 1-236; February, pp. 23...
- Journal Based CME Instructions and Information
- Cover Sheet for Index
- In the blink of an eye
- Langerhans cell histiocytosis in children
- Instagram and the dermatologist: An ethical analysis
- Chemical characterization of PM 2.5 from a souther...
- Mitochondrial Translation Efficiency Controls Cyto...
- The Polycomb-Dependent Epigenome Controls β Cell D...
- Arginase 2 Suppresses Renal Carcinoma Progression ...
- Early Time-Restricted Feeding Improves Insulin Sen...
- Low-temperature co-purification of NO x and Hg 0 f...
- Generalized urticaria caused by ingestion of sweet...
- Acquisition of tolerance to egg allergy in a child...
- Implication of fraction of exhaled nitric oxide an...
- A Combinatorial Lipid Code Shapes the Electrostati...
- Ingestion of Food Particles Regulates the Mechanos...
- PCYT1A Regulates Phosphatidylcholine Homeostasis f...
- Intracellular Calcium Mobilization Is Required for...
- Analyzing the uncertainty of diffusive gel-based p...
- Accelerated carbonation of wood combustion ash for...
- Dynamic filtration and static adsorption of lead i...
- Clonal neutrophil infiltrates in concurrent Sweet'...
- Non-Invasive Early Detection of Malignant Pulmonar...
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- Chronic hyperinsulinemia promotes meta-inflammatio...
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- Medical and dietary management of eosinophilic eso...
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- Efficacy of a single dose of omalizumab for the pr...
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- Le diagnostic de FPI : un long fleuve tranquille ?
- La chimiothérapie inhalée – partie 2 : clinique et...
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- L’interprétation des EFR peut-elle encore faire l’...
- Limite inférieure de la normale ou ratio fixe pour...
- Septic arthritis of the sternoclavicular joint: A ...
- Total mandibulectomy defect in the setting of chro...
- Preparation breeds success: Brain activity predict...
- Episodic memory for natural and transformed food
- An empirical, 21st century evaluation of phrenology
- Variations within a subtype: Developmental surface...
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- Preclinical characterization and clinical evaluati...
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- Constraints on somatosensory map development: muta...
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- Roxithromycin monotherapy inducing a partial respo...
- Corrigendum to “Complications During Ketogenic Die...
- Antibiotic resistance in severe odontogenic infect...
- Genome sequencing and functional characterization ...
- Multifunctional NIR-responsive PVP-Cu-Sb-S nanothe...
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