The safety of trifluridine and tipiracil for the treatment of metastatic colorectal cancer.

The safety of trifluridine and tipiracil for the treatment of metastatic colorectal cancer.

Expert Opin Drug Saf. 2018 May 10;:

Authors: Martinez-Perez J, Riesco-Martinez MC, Garcia-Carbonero R

Abstract
INTRODUCTION: TAS102 is an oral thymidine-based nucleoside analogue that has been approved for the treatment of patients with metastatic colorectal cancer (mCRC) previously treated with, or not candidates for, available therapies including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-vascular endothelial growth factor (VEGF) agents and, if RAS wild-type, anti-epidermal growth factor receptor (EGFR) therapy. The pivotal RECOURSE phase III trial demonstrated a significant improvement in disease control rate, progression-free (PFS) and overall survival (OS) as compared with placebo in patients with refractory mCRC. Areas covered: This manuscript aims to review the clinical development of TAS102 in CRC, with a particular focus on safety, and to provide some perspective regarding its role in clinical practice. A literature search was conducted of MEDLINE and EMBASE databases for published studies (Jan 2004-Dec 2016) using the search terms TAS102, trifluridine-tipiracil, metastatic or advanced CRC, clinical trial, toxicity, safety, pharmacology, pharmacokinetics and therapy. Expert opinion: TAS102 significantly improves survival of patients with refractory mCRC and has manageable toxicity. An expanding role in the treatment of CRC is expected for TAS102 in the near future, as its favorable safety profile makes TAS102 a suitable drug to be combined with other cytotoxic and targeted agents.

PMID: 29745737 [PubMed - as supplied by publisher]

https://ift.tt/2KTtU5N