Tuberous sclerosis complex (TSC) causes the formation of hamartomatous tumors in multiple organs. Facial angiofibromas frequently arise during childhood and can be a source of patient distress owing to bleeding and effects on appearance. The standard treatment is surgical, delivered by multiple modalities, including lasers, shave excision, dermabrasion, electrosurgery, or cryosurgery. These approaches are effective but can create concerns about the potential for scarring, pain, anesthesia risk, postoperative recovery, and the need for repeated procedures delivered in the office or operating room. Consequently, there has been interest in the development of a topical therapy for home use that is painless and nonscarring. In this issue, Koenig and collaborators show that topical 0.1% or 1.0% sirolimus (rapamycin) applied once daily is safe and effective for treating facial angiofibromas. This is welcome news for many with TSC. Furthermore, these results are expected to fuel investigations into other uses for sirolimus in dermatology. The story of how topical sirolimus became a treatment option for TSC is based in scientific discoveries of its molecular target and that target's role in relevant diseases.
https://ift.tt/2s70uIU
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Novel autosomal recessive LAMA3 and PLEC variants ...
- Varicella zoster virus as a possible trigger for t...
- Manipulating macrophage polarization and function ...
- Effects of treatment with an angiotensin 2 recepto...
- A pedunculated aldosterone‐producing adenoma drain...
- Long‐term outcomes and molecular analysis of a lar...
- Young age is associated with increased rates of re...
- Chronic Urticaria: Comparisons of US, European, an...
- Trapping fresh sea breeze in desert? Health status...
- Split-thickness skin grafting using grafts of diff...
- FACE‐Q Skin Cancer Module for measuring patient‐re...
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- Anthropogenic activities impact on atmospheric env...
- Chronic Urticaria: Comparisons of US, European, an...
- Bullous pemphigoid complicated by necrotising fasc...
- Eyelid sebaceous carcinoma in situ presenting as h...
- Bullous pemphigoid complicated by necrotising fasc...
- Eyelid sebaceous carcinoma in situ presenting as h...
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- The mediating role of phosphodiesterase type 4 in ...
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- Two single-nucleotide polymorphisms of the RELN ge...
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- A prospective observational study of pigmented nae...
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- Acute generalized exanthematous pustulosis due to ...
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- Rosacea‐like cutaneous localization of small lymph...
- The significance of spectrophotometric image analy...
- Split‐axilla comparison study of 0.5‐MHz, invasive...
- Detection of hydroquinone by Raman spectroscopy in...
- Anesthesia effects on the low frequency blood flow...
- Sequels to tattoo removal by caustic products
- Use of silicone gel to enhance skin wound healing ...
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- Chilblains accompanying interleukin‐1 receptor‐ass...
- Pemphigus foliaceus and acquired haemophilia: a ra...
- Development of angio‐oedema after omalizumab injec...
- Disseminated interstitial granuloma annulare assoc...
- Intravenous immunoglobulins in dermatology. Part 1...
- Intravenous immunoglobulins in dermatology. Part 2...
- Comparison of PCR‐based methods for the diagnosis ...
- When passion hurts: adverse cutaneous reaction to ...
- Cutaneous melanoma in France in 2015 attributable ...
- Systematic review of platelet‐rich plasma (PRP) pr...
- Split face comparison between common concentration...
- JCD Commentary—June 2018
- Issue Information
- Prevalence and risk factors for injection site ski...
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