Role of MAIT cells in pulmonary bacterial infection

Publication date: September 2018
Source:Molecular Immunology, Volume 101
Author(s): Nadine Hartmann, Melanie J. Harriff, Curtis P. McMurtrey, William H. Hildebrand, David M. Lewinsohn, Mitchell Kronenberg
Mucosal-associated invariant T (MAIT) cells represent a population of innate T cells that is highly abundant in humans. MAIT cells recognize metabolites of the microbial vitamin B pathway that are presented by the major histocompatibility complex (MHC) class I-related protein MR1. Upon bacterial infection, activated MAIT cells produce diverse cytokines and cytotoxic effector molecules and accumulate at the site of infection, thus, MAIT cells have been shown to be protective against various bacterial infections. Here, we summarize the current knowledge of the role of MAIT cells in bacterial pulmonary infection models.



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