Viral Vectors for Studying Brain Mechanisms that Control Energy Homeostasis

Publication date: 5 June 2018
Source:Cell Metabolism, Volume 27, Issue 6
Author(s): Giacomo Mancini, Tamas L. Horvath
Viral vectors have been shown to be potent and versatile tools for genome editing. In the present Minireview, we focus on lentiviruses and adeno-associated viruses as vectors and their use in the study of the hypothalamic circuits involved in the regulation of energy homeostasis.

Teaser

Genetically modified adeno-associated viruses represent an extremely useful technology for delivering genetically encoded tools into cells both in vitro and in vivo. Mancini and Horvath review essential techniques for the implementation of viral versatility and specificity to study brain circuits involved in the regulation of energy metabolism.


https://ift.tt/2sJk9ip