Metabolic Stress, Autophagy, and Cardiovascular Aging: from Pathophysiology to Therapeutics

Publication date: Available online 22 August 2018

Source: Trends in Endocrinology & Metabolism

Author(s): Jun Ren, James R. Sowers, Yingmei Zhang

Recent advances in health care have improved the management of cardiometabolic disorders, and prolonged lifespan. However, the ever-rising prevalence of metabolic stress related to obesity (insulin resistance, diabetes, hypertension, and dyslipidemia) has greatly challenged geriatric care. The ubiquitin–proteasome system and autophagy–lysosomal pathways represent two major, yet distinct cellular machineries, for degradation and removal of damaged or long-lived proteins and organelles; the function of which declines with aging. To seek new strategies for cardiovascular aging under various metabolic diseases, it is imperative to understand the precise role for metabolic stress and protein quality control, in particular autophagy, in premature cardiovascular aging. Targeting metabolic stress and autophagy may offer exciting new avenues for the management of cardiovascular aging.

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