The Effect of Histidine-Tryptophan-Ketoglutarate Solution (HTK) and University of Wisconsin Solution (UW): an Analysis of the Eurotransplant Registry

Background Both UW and HTK are currently used in the Eurotransplant region for preservation of liver allografts. Previous studies on their effect have led to a lot of discussion. This study aims to compare the effect of HTK and UW on graft survival. Methods First liver transplantations in recipients ≥18 years from 1.1.2007 until 31.12.2016 were included. Graft survival was compared for livers preserved with HTK and UW at 30 days, 1, 3 and 5-years. Multivariable analysis of risk factors was performed and outcome was adjusted for important confounders. Results Of all 10,628 first liver transplantations, 8,176 (77%) and 2,452 (23%) were performed with livers preserved with HTK and UW, respectively. Kaplan-Meier curves showed significant differences in graft survival between HTK and UW at 30 days (89% vs 93%, p=

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