Comparison of comorbid diagnoses in children with and without eosinophilic esophagitis in a large population

Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory condition characterized by esophageal dysfunction with associated eosinophilic infiltration of the esophageal mucosa, occurring in 1/2000 individuals.1,2 Since the 1990s, EoE has been recognized as a clinically distinct condition, being seen with increasing incidence and prevalence over time, and currently accounting for the most common cause of chronic dysphagia in pediatric patients in the developed world.3-6 The pathophysiology is frequently recognized as a food allergy-driven process, characterized by a TH2-type immune response, with a high rate of concomitant IgE-mediated food allergy observed in patients.

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