Pulse Pressure and Outcome in Kidney Transplantation: Results From the Collaborative Transplant Study

Background Systolic (SBP) and diastolic blood pressure (DBP) are important predictors of graft and patient survival in renal transplantation. Pulse pressure (PP), the difference between systolic and diastolic pressure, has been associated with cardiovascular and renal morbidity in nontransplant epidemiological studies and clinical trials. Methods In this large retrospective analysis of prospectively collected data, transplant recipients from 1995 to 2015 were examined for patient and death-censored graft survival. Results In 43 006 recipients a higher 1-year PP was significantly associated with inferior 10-year patient and death-censored graft survival. In patients aged ≥60 SBP but not DBP was associated with 10-year survival, an effect that was pronounced in patients with a normal SBP of

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