A systematic review of randomised controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

Summary

The clinical sequelae of oestrogen deficiency during menopause are undoubted. However, the pathophysiological role of testosterone during the menopause is less clear. Several randomised, placebo–controlled clinical trials suggest that testosterone therapy improves sexual function in post‐menopausal women. Some studies suggest that testosterone therapy has additional effects which include increased bone mineral density and decreased serum high density lipoprotein (HDL) cholesterol. Furthermore, the long‐term safety profile of testosterone therapy in post‐menopausal women is not clear. This article will provide a concise and critical summary of the literature, to guide clinicians treating post‐menopausal women.

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