Postprandial decline in thyroid-stimulating hormone is significant but not its correlation with postprandial change in plasma glucose

T V S Pradeep, Sree Harsha Varma, Sunanda Tirupati, Vijaya Sarathi, K Dileep Kumar

Thyroid Research and Practice 2018 15(3):113-116

Background: There are limited data on postprandial change in serum thyroid-stimulating hormone (TSH), especially on its correlation with postprandial change in plasma glucose. Hence, we evaluated the postprandial changes in thyroid function tests (TFTs) and their correlation with postprandial changes in plasma glucose. Materials and Methods: This prospective, cross-sectional study was conducted at a tertiary care hospital from South India. The study included 200 participants: 75 healthy volunteers without known thyroid dysfunction (Group A), 65 healthy pregnant women (Group B), and 60 patients who were known hypothyroid (clinical and subclinical hypothyroid) on levothyroxine therapy (Group C). All participants underwent biochemical investigations including plasma glucose and TFTs in fasting and 2-h postprandial states. Results: Serum TSH was significantly lower in the postprandial state than fasting sample in all the three groups, whereas the free triiodothyronine and free thyroxine levels were not significantly different in fasting and postprandial states. There was no significant correlation between change in plasma glucose and the change in TFT in any group. In pregnant women (Group B), the prevalence of hypothyroidism was significantly higher in fasting than postprandial while using a cutoff of 2.5 μIU/ml (41.5% vs. 18.4%, P = 0.004) as well as 4 μIU/ml (12.3% vs. 1.5%, P = 0.03) but not in other groups (Group A and Group C). Conclusion: Our study reports significant TSH decline in the postprandial state but no significant correlation between postprandial changes in plasma glucose and TSH.

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