Macrophage polarization: reaching across the aisle?

Publication date: Available online 9 January 2019

Source: Journal of Allergy and Clinical Immunology

Author(s): Maria Carla Bosco

Abstract

Macrophage polarization may influence the pathogenesis of many human diseases; however the transcriptional program regulating this process remains poorly characterized. Gharib et al.¹ highlight the high diversity of M1-to-M2 re-polarization exerted by distinct M2 stimuli via transcriptome-based pathway analysis and provide a new approach to phenotype human macrophages in clinically relevant disease states such as cystic fibrosis and asthma

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