Primary Cutaneous Hodgkin‐like Polymorphic Post‐Transplant Lymphoproliferative Disorder

Post‐transplant lymphoproliferative disorder (PTLD) is an uncommon complication after solid organ transplants and hematopoietic stem cell transplants. Isolated involvement of the skin without systemic involvement in PTLD is extremely rare. Primary cutaneous PTLD is generally categorized as either cutaneous T‐cell lymphomas or cutaneous B‐cell lymphomas, with variable Epstein‐Barr virus (EBV) positivity. Herein, we describe an exceedingly uncommon case of a primary cutaneous Hodgkin‐like polymorphic PTLD. A man in his 60s, with a history of kidney transplant, presented with a 5‐week history of 2 indurated plaques. Clinical, histologic and immunohistochemical findings were consistent with primary cutaneous Hodgkin‐like polymorphic PTLD. Reduction in immunosuppression led to resolution of his lesions. This case highlights a rare case of primary cutaneous Hodgkin‐like PTLD and increases awareness of this uncommon post‐transplant complication. It also underscores the importance of collaboration between dermatology, hematology, dermatopathology and hematopathology in order to diagnose challenging cases.

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