ACMSD: A Novel Target for Modulating NAD+ Homeostasis

Publication date: Available online 21 February 2019

Source: Trends in Endocrinology & Metabolism

Author(s): Jun Yoshino

NAD⁺ has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD⁺ metabolism and overexpression of human ACMSD leads to niacin dependency for NAD⁺ biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD⁺ deficiency.

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