Anticatabolic Effects of Ketone Bodies in Skeletal Muscle

Publication date: Available online 31 January 2019

Source: Trends in Endocrinology & Metabolism

Author(s): Andrew P. Koutnik, Dominic P. D'Agostino, Brendan Egan

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) are the subject of renewed interest given recently established pleiotropic effects regulating inflammation, oxidative stress, and gene expression. Anticatabolic effects of β-hydroxybutyrate have recently been demonstrated in human skeletal muscle under inflammatory insult, thereby expanding upon the wide-ranging therapeutic applications of nutritional ketosis.

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