A Case of Metastatic Thymoma Responsive to Treatment With 177Lu-DOTATATE

alexandrossfakianakis shared this article with you from Inoreader A Case of Metastatic Thymoma Responsive to Treatment With 177Lu-DOTATATE via Clinical Nuclear Medicine - Published Ahead-of-Print We describe a case of a 74-year-old woman with germline BRCA2 mutation, with an incidental diagnosis of metastatic thymoma presenting as a mediastinal mass with cardiac muscle and lymph node involvement. Despite surgical and radiotherapy treatment, there was marked advancement with new lung and liver metastases. All lesions demonstrated 68Ga-DOTATATE PET/CT uptake, and the patient received 4 peptide receptor radionuclide therapy cycles with 177Lu-DOTATATE, with pronounced reduction in the size of the liver, cardiac, and pleural lesions. This is the first case to demonstrate partial response to peptide receptor radionuclide t herapy in metastatic thymoma, thus suggesting possible treatment option to refractory and advancing metastatic thymoma. View on Web

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