Adaptive immune regulation in autoimmune diabetes

Publication date: Available online 26 November 2015
Source:Autoimmunity Reviews
Author(s): Concetta Ferretti, Antonio La Cava
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss of insulin-producing pancreatic β cells. The pathogenesis of T1D is complex and multifactorial and involves a genetic susceptibility that predisposes to abnormal immune responses in the presence of ill-defined environmental insults to the pancreatic islets. This review discusses how adaptive immunoregulatory T cells contribute to the modulation of the development and evolution of T1D, together with potential approaches that target these cells for new therapies in the disease.



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