Expression of dermcidin in sebocytes supports a role for sebum in the constitutive innate defense of human skin

Sebaceous glands (SGs) are epidermal appendages normally found in association with a hair follicle, forming the pilosebaceous unit. Numerous functions have been attributed to SGs, including roles in epidermal barrier, hair follicle integrity, as well as antioxidant and antimicrobial properties. Furthermore, altered SG activity is an important component of several skin diseases such as acne and cicatricial alopecia. Sebocytes, the secretory cells within SGs, synthesize and accumulate large amounts of lipids, and eventually release their product (sebum) into the hair canal by holocrine secretion [1].

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