Choline-based imaging of prostate cancer with combined [18F] fluorocholine PET and 1H MR spectroscopy by means of integrated PET/MRI

Publication date: Available online 7 January 2017
Source:Clinical Imaging
Author(s): Axel Wetter, Johannes Grüneisen, Klaus Fliessbach, Susanne Lütje, Benedikt Schaarschmidt, Lale Umutlu
PurposeTo evaluate integrated PET/MRI/¹H MR spectroscopy in patients with prostate cancer.Subjects and methodsData analysis comprised calculations of correlations of standardized uptake values (SUVs) and ratios of (choline+creatine)/citrate as well as of single metabolite values and a logistic regression analysis of PET data and MR spectroscopy data in 22 patients.ResultsSUVmean and integral values of choline correlated significantly in tumors. Logistic regression analysis demonstrated diagnostic superiority of PET over spectroscopy.ConclusionSimultaneous acquisition of PET and MR spectroscopy with integrated PET/MRI is feasible. Choline compounds and choline metabolism show a positive significant correlation.



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