Preliminary investigation of whole-pancreas 3D histogram ADC metrics for predicting progression of acute pancreatitis

Publication date: March–April 2017
Source:Clinical Imaging, Volume 42
Author(s): Amir K. Iranmahbook, Andrea S. Kierans, Chenchan Huang, Justin M. Ream, Andrew B. Rosenkrantz
PurposeTo evaluate whole-pancreas 3D-histogram ADC metrics in acute pancreatitis.MethodsIn 41 patients with acute pancreatitis undergoing MRI/MRCP with DWI, 3D-volumes-of-interest encompassing the entire pancreas were placed to derive whole-pancreas histogram ADC metrics.ResultsThere were trends toward higher 0–10th percentile ADC, higher 10–25th percentile ADC, lower skewness, and higher kurtosis in patients with new complications (p=0.065–0.095). Conventional mean ADC showed no association with new complications (p=0.203). Kurtosis had highest area-under-the-curve (0.784) for predicting new complications (sensitivity=75.0%; specificity=91.9%).ConclusionFindings suggest whole-pancreas histogram ADC metrics assist early management of acute pancreatitis, (e.g., patient selection for more intensive monitoring/intervention).



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