Disruption of aromatase homeostasis as the cause of a multiplicity of ailments: A comprehensive review

Publication date: Available online 18 January 2017
Source:The Journal of Steroid Biochemistry and Molecular Biology
Author(s): Seema Patel
Human health is beset with a legion of ailments, which is exacerbated by the lifestyle errors. Out of the numerous enzymes in human body, aromatase, a cytochromes P450 enzyme is particularly very critical. Occurring at the crossroads of multiple signalling pathways, its homeostasis is vital. Unfortunately, medications, hormone therapy, chemical additives in food, and endocrine-disrupting personal care products are oscillating the aromatase concentration beyond the permissible level. As this enzyme converts androgens (C19) into estrogens (C18), its agitation has different outcomes in different genders and age groups. Some common pathologies associated with aromatase disruption include breast cancer, prostate cancer, polycystic ovary syndrome (PCOS), endometriosis, osteoporosis, ovarian cancer, gastric cancer, pituitary cancer, Alzheimer's disease, schizophrenia, male hypogonadism, and transgender issues. Several drugs, personal consumer products and pesticides act as the activators and suppressors of this vital enzyme. This carefully-compiled critical review is expected to increase public awareness regarding the threats resultant of the perturbations of this enzyme and to motivate researchers to further investigate this field.



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