Σφακιανάκης Αλέξανδρος
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Σάββατο 21 Ιανουαρίου 2017

Impact of G protein-coupled receptor heteromers in endocrine systems

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Publication date: Available online 20 January 2017
Source:Molecular and Cellular Endocrinology
Author(s): K.C. Jonas, A.C. Hanyaloglu
The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated processes. The superfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrine axes, thus understanding the mechanisms underpinning their functionality is paramount for treatment of endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as a key mode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerization and its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploring current and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrine heath and disease.



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