Publication date: March 2017
Source:International Immunopharmacology, Volume 44
Author(s): Cheng-Foh Le, Thina Hareesh Kailaivasan, Sek-Chuen Chow, Zunoliza Abdullah, Sui-Kiong Ling, Chee-Mun Fang
Clinacanthus nutans (Burm. f.) Lindau is a traditional medicinal plant belonging to the Acanthaceae family. Its therapeutic potentials have been increasingly documented particularly the antiviral activity against Herpes Simplex Virus (HSV), anti-cancer, anti-oxidant, anti-inflammatory and immunomodulatory activities. However, majority of these studies used crude or fractionated extracts and not much is known about individual compounds from these extracts and their biological activities. In the present study, we have isolated four compounds (CN1, CN2, CN3 and CN4) from the hexane fractions of C. nutans leaves. Using NMR spectroscopic analysis, these compounds were identified to be shaftoside (CN1), stigmasterol (CN2), β-sitosterol (CN3) and a triterpenoid lupeol (CN4). To determine the immunosuppressive potential of these compounds, their effects on mitogens induced T and B lymphocyte proliferation and the secretion of helper T cell cytokines were examined. Among the four compounds, stigmasterol (CN2) and β-sitosterol (CN3) were shown to readily inhibit T cell proliferation mediated by Concanavalin A (ConA). However, only β-sitosterol (CN3) and not stigmasterol (CN2) blocks the secretion of T helper 2 (Th2) cytokines (IL-4 and IL-10). Both compounds have no effect on the secretion of Th1 cytokines (IL-2 and IFN-γ), suggesting that β-sitosterol treatment selectively suppresses Th2 activity and promotes a Th1 bias. CN3 was also found to significantly reduce the proliferation of both T helper cells (CD4+CD25+) and cytotoxic T cells (CD8+CD25+) following T cell activation induced by ConA. These results suggested that phytosterols isolated from C. nutans possess immunomodulatory effects with potential development as immunotherapeutics.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Σάββατο 21 Ιανουαρίου 2017
Phytosterols isolated from Clinacanthus nutans induce immunosuppressive activity in murine cells
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- A comparison of antibacterial and antibiofilm effi...
- Bilateral Tensor Fasciae Suralis Muscles in a Cada...
- Positively charged phthalocyanine-arginine conjuga...
- Inhibitors of nuclease and redox activity of apuri...
- A stereoselective, catalytic strategy for the in-f...
- TRIM Family Proteins: Roles in Autophagy, Immunity...
- A Golden Age for Working with Public Proteomics Data
- Comparison of the local effects of a 600-μm bare f...
- In vivo near-infrared imaging and phototherapy of ...
- Tackling the salinity-pollution nexus in coastal a...
- Influence of environmental and anthropogenic facto...
- Symptom burden and dysphagia associated with osteo...
- Effects of two grading techniques of zirconia mate...
- Crystallization kinetics of syndiotactic polypropy...
- Highly-branched cross-linked poly(ethylene oxide) ...
- Crosslinking of an ethylene-glycidyl methacrylate ...
- It is important to measure changes in the bone-con...
- Cochlear duct length–one size fits all?
- It is important to measure changes in the bone-con...
- Cochlear duct length–one size fits all?
- MYSM1 deficiency - genotoxic stress-associated bon...
- Damaging heterozygous mutations in NFKB1 lead to d...
- Iron Mapping in Multiple Sclerosis
- Conductive nanogel-interfaced neural microelectrod...
- Fibroin particle-supported cationic lipid layers f...
- Aurantiamide Acetate from Baphicacanthus cusia roo...
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- Hawthorn (Crataegus pinnatifida Bunge) leave flavo...
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- Water extract of Helminthostachys zeylanica attenu...
- Antiosteoporotic Effect of Hemidesmus indicus Linn...
- Editorial Board
- Chorda tympani nerve management in endoscopic stap...
- Chorda tympani nerve management in endoscopic stap...
- Vertical supranuclear gaze palsy in a toddler with...
- Management of the clinically node negative neck in...
- Analysis of 22Na using a spectral summation techni...
- On the divergences in assessment of environmental ...
- The possible role of cerium oxide (CeO2) nanoparti...
- Prospective comparative study between un-enhanced ...
- Evidence-based health and clinical informatics: a ...
- Changes in fMRI activation in anterior hippocampus...
- Tumor necrosis factor-alpha inhibitors suppress CC...
- Tumor necrosis factor-alpha inhibitors suppress CC...
- Effect of Mastoid Drilling on Hearing of the Contr...
- Effect of Mastoid Drilling on Hearing of the Contr...
- Electroencephalographic characteristics of status ...
- Effect of piroxicam on lipid membranes: Drug encap...
- Functional magnetic resonance imaging in dermatolo...
- Effect of 6-gingerol on AMPK- NF-κB axis in high f...
- Cutaneous alternariosis in a renal transplant pati...
- Cranial Nerve Injury After Carotid Endarterectomy:...
- 6th ESSD Congress Milan 2016 Abstract Book
- In-vitro performance of CAD/CAM-fabricated implant...
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- The effect of the Physical Consistency of the Diet...
- Similarities and Differences between Porcine Mandi...
- Dental occlusion analysis in the Mesolithic–Neolit...
- In vivo magnetic resonance imaging investigating t...
- Cell cycle-tailored targeting of metastatic melano...
- CD4+TCRγδ+FoxP3+cells: An unidentified population ...
- Langerhans cell markers CD1a and CD207 are the mos...
- Reduced proliferation and colony formation of head...
- Effect of Mastoid Drilling on Hearing of the Contr...
- An Overview of Autosomal Dominant Tumour Syndromes...
- Effect of Mastoid Drilling on Hearing of the Contr...
- An Overview of Autosomal Dominant Tumour Syndromes...
- Soil compaction effects on soil health and croppro...
- Adsorption of nickel ions by oleate-modified magne...
- An Overview of Autosomal Dominant Tumour Syndromes...
- Biochemical and physiological responses of halophi...
- Association between heavy metal and metalloid leve...
- Heavy metals and nutrients (carbon, nitrogen, and ...
- The nexus of oil consumption, CO 2 emissions and e...
- Assessment of biological, psychological and adhere...
- Chloride ion transport and overexpression of TMEM1...
- Use of baked milk challenges and milk ladders in c...
- Maternal psychiatric symptoms during pregnancy and...
- Assessment of biological, psychological and adhere...
- Chloride ion transport and overexpression of TMEM1...
- Use of baked milk challenges and milk ladders in c...
- Maternal psychiatric symptoms during pregnancy and...
- Cadherin-11 as a therapeutic target in chronic, in...
- Cadherin-11 as a therapeutic target in chronic, in...
- Les néoplasies intra-épithéliales bowénoïdes HPV-i...
- Development of a model to predict the 10-year cumu...
- Les néoplasies intra-épithéliales bowénoïdes HPV-i...
- Splenic Enlargement and Bone Marrow Hyperplasia in...
- Vomero-premaxillary joint: A marker of evolution o...
- Quality of life impairment in patients with head a...
- Fungal periprosthetic joint infection following to...
- Fungal periprosthetic joint infection following to...
- CXCR4 antagonist AMD3100 reverses the neurogenesis...
- Effect of ZBD-2 on chronic pain, depressive-like b...
- Modulation on brain gray matter activity and white...
- Virtual reality conditioned place preference using...
- The effects of neonatal amygdala or hippocampus le...
- Unraveling the Role of Ataxin-2 in Metabolism
- Reply to Vinson et al.
- Hemorrhagic Pericardial Cyst Diagnosis Accelerated...
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