Janus-kinase inhibitors display broad anti-itch properties – a possible link via the TRPV1 receptor

Publication date: Available online 26 January 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Tomoki Fukuyama, Joy Rachel Ganchingco, Santosh K. Mishra, Thierry Olivry, Ignacy Rzagalinski, Dietrich A. Volmer, Wolfgang Bäumer

Teaser

The antipruritic effect of JAK inhibitors is fast and sustained in dogs with atopic dermatitis and in human patients with psoriasis. The inhibitory profiles of these molecules might be more related to their direct inhibition of TRPV1 rather than that of JAKs.


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