Total Synthesis and Cytotoxicity of Leucetta Alkaloids

Publication date: Available online 20 January 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Panduka B. Koswatta, Sabha Kasiri, Jayanta Das, Arunoday Bhan, Heather M. Lima, Beatriz Garcia-Barboza, Nicole N. Khatibi, Muhammed Yousufuddin, Subhrangsu S. Mandal, Carl J. Lovely
The total synthesis of a number of representative natural products isolated from Leucetta and Clathrina sponges containing a polysubstituted 2-aminoimidazole are described. These syntheses take advantage of the site specific metallation reactions of 4,5-diiodoimidazoles resulting in the syntheses of three different classes of Leucetta derived natural products. The cytotoxicities of these natural products, along with several precursors in MCF7 cells were determined through an MTT growth assay. For comparative purposes a series of naphthimidazole-containing family members are included.

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