Acquired Hair Curling after Diphenylcyclopropenone Immunotherapy in Alopecia Areata Patient

Abstract

Contact immunotherapy using diphenylcyclopropenone (DPCP) is commonly used treatment modality for moderate to severe alopecia areata (AA)¹. The most common side effects associated with topical immunotherapy using DPCP include eczema, hyperpigmentation, hypopigmentation, vitiligo, and cicatricial alopecia.

However, we identified an interesting case of a patient whose entire scalp of straight hair (Figure 1A) became curly after DPCP immunotherapy, which has not been reported previously. A 24-year-old male patient with no specific medical or dermatological history reported to our dermatology outpatient clinic because of sudden hair loss and started treatment after being diagnosed with AA.

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