Presence of cutaneous human papillomavirus DNA in squamous cell carcinoma of the scalp: a case series

Abstract

Various hypotheses have been put forward on the pathogenesis of squamous cell carcinoma (SCC), including chronic sun damage and exposure to ultraviolet radiation (UVR), chemicals, smoking, immunosuppressive medications and human papillomavirus (HPV)¹.

It is well known that alpha (mucosal) HPV types, in particular HPV-16 and HPV-18, are etiologically correlated to cervical cancer and other types of anogenital carcinoma and oropharyngeal papillomatosis¹. On the contrary, the pathogenesis of squamous cell carcinoma (SCC) outside the mucosae remains obscure, and the link with HPVs has been demonstrated only in the epidermodysplasia verruciformis context^2-3.

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