Relationship between the time to locoregional recurrence and survival in laryngeal squamous-cell carcinoma.

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Relationship between the time to locoregional recurrence and survival in laryngeal squamous-cell carcinoma.

Eur Arch Otorhinolaryngol. 2017 Feb 09;:

Authors: Gorphe P, Tao Y, Blanchard P, Even C, Moya-Plana A, Mirghani H, Nguyen F, Temam S, Janot F

Abstract
To assess the relationship between the locoregional disease-free interval after treatment of the primary tumor and survival after a recurrence in patients with laryngeal carcinoma. We retrospectively investigated patients treated in our Cancer Center for a laryngeal cancer who subsequently developed a locoregional recurrence and were followed up until death. Post-recurrence survival was defined as the time from the locoregional recurrence to death. One hundred and twenty-three patients were included. Median post-recurrence survival was 7 months. The locoregional disease-free interval (LRDFI) after treatment of the primary was weakly correlated with post-recurrence survival (r = 0.210, p = 0.020). A LRDFI cut-off of 12 months was a significant prognostic factor (p = 0.005; median, 5 months, 95% CI: 2.239-6.761, vs 10 months, 95% CI: 7.270-12.730). The time to locoregional recurrence in laryngeal cancer was a prognostic factor correlated with post-recurrence survival. Locoregional failure within the first year after treatment of the primary tumor was associated with an unfavorable prognosis.

PMID: 28185009 [PubMed - as supplied by publisher]

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