| Related Articles |
The value of diagnostic bilateral intracranial EEG in treatment-resistant focal epilepsy.
World Neurosurg. 2017 Feb 06;:
Authors: Hill TC, Rubin BA, Tyagi V, Theobald J, Silverberg A, Miceli M, Dugan P, Carlson C, Doyle WK
Abstract
OBJECTIVES: We assessed the efficacy and risks of diagnostic bilateral intracranial EEG (bICEEG) in treatment-resistant epilepsy (TRE) patients with poorly lateralized epileptogenic zone (EZ) on non-invasive studies as reflected by progress to resection, Engel outcome and complication rate.
METHODS: This is a retrospective chart review of 199 patients with TRE who had diagnostic bICEEG at New York University Medical Center between 1994 and 2013. Study endpoints were progress to resection, surgical outcome and perioperative complications. Univariate analysis was performed with ANOVA, t-test or Fischer's Exact test; multivariable analysis was performed using discriminant function analysis.
RESULTS: bICEEG lateralized the EZ and the patient had resection in 60.3% of cases. The number of depth electrodes used was positively correlated with resection, and surgical complications during bICEEG negatively correlated. Vagal nerve stimulators were implanted in 58.2% of patients who did not undergo resection and 20.7% of those who did. Among the 87 patients who progressed to resection and had more than 1-year follow-up, 47.1% were seizure free compared with 12.7% of the 55 who did not. Male sex correlated with good postoperative seizure control. The most common complication was infection requiring debridement, occurring in 3.1% of admissions (9 of 290).
CONCLUSION: At our center, 60% of patients undergoing bICEEG progress to resection and 57% of these had more than 90% reduction in seizures. We conclude that bICEEG allows the benefits of epilepsy surgery to be extended to patients with poorly lateralized and localized TRE.
PMID: 28185968 [PubMed - as supplied by publisher]
http://ift.tt/2kz09tg
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου