Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity

Publication date: Available online 16 March 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Eric J. Allenspach, Laura S. Finn, Mara H. Rendi, Ahmet Eken, Akhilesh K. Singh, Mohamed Oukka, Sean D. Taylor, Matthew C. Altman, Corinne L. Fligner, Hans D. Ochs, David J. Rawlings, Troy R. Torgerson

Teaser

Regulatory T cells play a critical role in preventing fetal organ-specific autoimmunity in humans. Autopsies of neonatal IPEX patients shortly after birth demonstrate chronic exocrine-dominant pancreatitis with tertiary lymphoid structures containing expanded oligoclonal T/B lymphocytes.


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