Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart (†).

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Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart (†).

Artif Cells Nanomed Biotechnol. 2017 Feb 08;:1-8

Authors: Wrobeln A, Schlüter KD, Linders J, Zähres M, Mayer C, Kirsch M, Ferenz KB

Abstract
The aim of this study was to prove whether albumin-derived perfluorocarbon-based nanoparticles (capsules) can operate as a novel artificial oxygen carrier in a rat Langendorff-heart perfusion model. Hearts perfused with capsules showed increased left ventricular pressure and rate pressure product compared to hearts perfused with pure Krebs-Henseleit (KH)-buffer. The capsules prevented the myocardium from functional fail when in their absence a noxious ischemia was observed. Capsules did not change rheological properties of KH-buffer and could repeatedly reload with oxygen. This albumin-derived perfluorocarbon-based artificial oxygen carrier preserved the function of rat hearts due to the transport of oxygen in a satisfactory manner. Because of these positive results, the functionality of the applied capsules should be verified in living animals.

PMID: 28278587 [PubMed - as supplied by publisher]

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