Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma.

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Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma.

Intern Med. 2016;55(13):1807-10

Authors: Kawakami T, Hirabayashi Y, Kawakami F, Isobe R, Kaneko N, Mimura Y, Ito T, Furuta K, Shimazaki M, Nakazawa H, Kitano K

Abstract
We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. These findings suggest that a drug-resistant influenza virus strain might selectively survive antiviral therapy in elderly patients with refractory malignant lymphoma undergoing multiple chemotherapies.

PMID: 27374689 [PubMed - indexed for MEDLINE]

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