Publication date: Available online 16 March 2017
Source:Neurobiology of Aging
Author(s): Francesca Boscia, Anna Pannaccione, Roselia Ciccone, Antonella Casamassa, Cristina Franco, Ilaria Piccialli, Valeria de Rosa, Antonio Vinciguerra, Gianfranco Di Renzo, Lucio Annunziato
Astrocyte dysfunction emerges early in Alzheimer's disease (AD) and may contribute to its pathology and progression. Recently, the voltage gated potassium channel KV3.4 subunit, which underlies the fast-inactivating K+ currents (IA), has been recognized to be relevant for AD pathogenesis and is emerging as a new target candidate for AD. In the present study, we investigated both in in vitro and in vivo models of AD the expression and functional activity of KV3.4 potassium channel subunits in astrocytes. In primary astrocytes our biochemical, immunohistochemical, and electrophysiological studies demonstrated a time-dependent upregulation of KV3.4 expression and functional activity after exposure to amyloid-β (Aβ) oligomers. Consistently, astrocytic KV3.4 expression was upregulated in the cerebral cortex, hippocampus, and cerebellum of 6-month-old Tg2576 mice. Further, confocal triple labeling studies revealed that in 6-month-old Tg2576 mice, KV3.4 was intensely coexpressed with Aβ in non-plaque associated astrocytes. Interestingly, in the cortical and hippocampal regions of 12-month-old Tg2576 mice, plaque-associated astrocytes much more intensely expressed KV3.4 subunits, but not Aβ. More important, we evidenced that the selective knockdown of KV3.4 expression significantly downregulated both glial fibrillary acidic protein levels and Aβ trimers in the brain of 6-month-old Tg2576 mice. Collectively, our results demonstrate that the expression and function of KV3.4 channel subunits are precociously upregulated in cultured astrocytes exposed to Aβ oligomers and in reactive astrocytes of AD Tg2576 mice.
http://ift.tt/2m8N0fk
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Η λίστα ιστολογίων μου
Παρασκευή 17 Μαρτίου 2017
The Expression and Activity of KV3.4 Channel Subunits Are Precociously upregulated in Astrocytes Exposed to Aβ oligomers and in Astrocytes of Alzheimer's Disease Tg2576 Mice
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- A newly discovered galagid fossil from Nakali, an ...
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- Hypersensitivity Pneumonitis in an 11-Year-Old Boy...
- Decreased Expression of B cell Maturation Antigen ...
- Pediatric Allergy, Immunology and Pulmonology Cele...
- Smoking Patterns and Perspectives of Families of I...
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- New Scoring System for Evaluating Patulous Eustach...
- A cross-sectional survey of the nature and correla...
- A chronic recurrent disease course of dermatomyosi...
- A preliminary investigation of noise impact within...
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- Dynamics of biochemical properties associated with...
- Degradation of n -alkanes and PAHs from the heavy ...
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