Publication date: April 2017
Source:Neurobiology of Aging, Volume 52
Author(s): Christiane Frahm, Akash Srivastava, Silvio Schmidt, Jule Mueller, Marco Groth, Madlen Guenther, Yuanyuan Ji, Steffen Priebe, Matthias Platzer, Otto W. Witte
The brain plays a central role in organismal aging but is itself most sensitive to aging-related functional impairments and pathologies. Insights into processes underlying brain aging are the basis to positively impact brain health. Using high-throughput RNA sequencing and quantitative polymerase chain reaction (PCR), we monitored cerebral gene expression in mice throughout their whole lifespan (2, 9, 15, 24, and 30 months). Differentially expressed genes were clustered in 6 characteristic temporal expression profiles, 3 of which revealed a distinct change between 24 and 30 months, the period when most mice die. Functional annotation of these genes indicated a participation in protection against cancer and oxidative stress. Specifically, the most enriched pathways for the differentially expressed genes with higher expression at 30 versus 24 months were found to be glutathione metabolism and chemokine signaling pathway, whereas those lower expressed were enriched in focal adhesion and pathways in cancer. We therefore conclude that brains of very old mice are protected from certain aspects of aging, in particular cancer, which might have an impact on organismal health and lifespan.
http://ift.tt/2mVSx7U
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Παρασκευή 17 Μαρτίου 2017
Transcriptional profiling reveals protective mechanisms in brains of long-lived mice
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- A cross-sectional comparison of ethanol-related cy...
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- Anesthesia in adults with congenital heart disease.
- Training future anesthesiologists in obstetric care.
- Update in pediatric anesthesiology.
- The American College of Surgeons Children's Surger...
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- Hypersensitivity Pneumonitis in an 11-Year-Old Boy...
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- Smoking Patterns and Perspectives of Families of I...
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- Voice outcomes post total laryngectomy.
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- Tests of Eustachian Tube Function: the Effect of T...
- Secondary Endolymphatic Hydrops.
- New Scoring System for Evaluating Patulous Eustach...
- A cross-sectional survey of the nature and correla...
- A chronic recurrent disease course of dermatomyosi...
- A preliminary investigation of noise impact within...
- Sorption and desorption of silver ions by bentonit...
- Dynamics of biochemical properties associated with...
- Degradation of n -alkanes and PAHs from the heavy ...
- Exploiting fruit byproducts for eco-friendly nanos...
- Determination of heavy metals in muscle tissue of ...
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- Spatiotemporal variability in salinity and hydraul...
- Nipple reconstruction with complementary triangula...
- Effect of acidity of in-office bleaching gels on t...
- Fully automated VMAT treatment planning for advanc...
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