A hypothesis for mechanism for brain edema due to glycine

Publication date: Available online 9 April 2017
Source:Medical Hypotheses
Author(s): Suchita J. Mehta, Andrea Roche Recinos, Subodh J. Saggi, Man S. Oh
Death following the use the glycine distension solution in transurethral prostatectomy (TURP) or hysteroscopic surgery has been attributed to the toxic effect of glycine on the brain through the glycine receptors and hyperammonemia, contending that glycine-associated hyponatremia is isosmotic and therefore would not cause brain edema. Here we propose a hypothesis that the mechanism of brain edema and death is actually osmotic brain edema caused by selective diffusion of glycine into the brain while sodium cannot diffuse out of the brain a despite favorable concentration gradient because of the absence of sodium transporter on the cerebral capillaries needed for the exit of sodium from the brain. The mechanism for unidirectional diffusion of solutes into the brain in glycine-associated hyponatremia is explained.



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