Author's response

Motivated by the article by Zazzali et al,1 my editorial2 was intended to elaborate on the possibility of having conflicting conclusions concerning clinical significance vs statistical significance. I would like to thank the authors for their constructive letter3 in support of clinical significance of the effects of omalizumab on angioedema in patients with chronic idiopathic/spontaneous urticaria. The statistical significance of the collective primary outcome differences in patients treated with an active intervention compared with a control is often assessed in terms of the difference in the outcome means for the treatments.

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